2000’s Heartthrob Gained Weight, Went Gray & Was Diagnosed with Serious Condition after ‘Prison Break’ – Before & after Pics

Wentworth Miller, who captivated audiences with his striking looks over 20 years ago, has since embraced a fuller figure and silver hair. From openly embracing his identity as a gay man to confronting a significant health diagnosis, his journey has been marked by profound change.

Wentworth Miller is widely recognized for his portrayal of Michael Scofield in the Fox series “Prison Break,” a role he played for 12 years starting in 2005. He has also appeared on “Law & Order: Special Victims Unit” and a notable presence on “The Flash.”

In addition to his successful Hollywood career, Miller has experienced profound changes both physically and emotionally. His journey has been shaped by personal challenges and growth. Here’s how his life struggles have influenced his transformation over the years.

Wentworth Miller trains for his upcoming role in Miramax's "The Human Stain" on March 3, 2002 in Hollywood, Utah. | Source: Getty Images

Wentworth Miller trains for his upcoming role in Miramax’s “The Human Stain” on March 3, 2002 in Hollywood, Utah. | Source: Getty Images

Miller in 2003

In August 2003, Miller posed during a photocall at the 60th Venice Film Festival. He had a clean-shaven face and short, closely cropped hair. His complexion was smooth, and he appeared lean. His appearance was polished yet relaxed, fitting for the summer event.

Wentworth Miller poses during a photocall at the 60th Venice Film Festival August 29, 2003, in Venice, Italy. | Source: Getty Images

Wentworth Miller poses during a photocall at the 60th Venice Film Festival August 29, 2003, in Venice, Italy. | Source: Getty Images

The next month, at the Toronto International Film Festival, Miller attended a press conference. His hairstyle remained short and neat, similar to the previous month. He was clean-shaven, emphasizing his sharp jawline. His physique still appeared slender, maintaining his youthful, fresh-faced appearance.

Wentworth Miller attends the press conference at the 2003 Toronto International Film Festival on September 7, 2003, in Toronto, Canada. | Source: Getty Images

Wentworth Miller attends the press conference at the 2003 Toronto International Film Festival on September 7, 2003, in Toronto, Canada. | Source: Getty Images

He attended another event the following month at ArcLight Cinemas in Hollywood, where his appearance showed subtle changes. He maintained a consistent look as his physique remained trim, reflecting no significant changes in weight.

Wentworth Miller attends the Hollywood Film Festival Screening of "The Human Stain" on October 21, 2003 in Hollywood, California. | Source: Getty Images

Wentworth Miller attends the Hollywood Film Festival Screening of “The Human Stain” on October 21, 2003 in Hollywood, California. | Source: Getty Images

Miller in 2005

At the Fox Primetime Upfront event in May 2005, Miller displayed a polished, clean look. His hair was short and neatly trimmed, and he was clean-shaven, showcasing his defined facial features. His physique appeared lean, maintaining his trim build.

Wentworth Miller during 2005/2006 FOX Primetime UpFront on May 19, 2005, in Central Park, New York City. | Source: Getty Images

Wentworth Miller during 2005/2006 FOX Primetime UpFront on May 19, 2005, in Central Park, New York City. | Source: Getty Images

While on the set of “Prison Break,” that same year, Miller’s appearance was consistent with his previous looks. He kept his hair short and neat, and his face remained clean-shaven.

Wentworth Miller on the set of "Prison Break," 2005 | Source: Getty Images

Wentworth Miller on the set of “Prison Break,” 2005 | Source: Getty Images

Another photo from the “Prison Break” set showed Miller maintaining his signature style. His hair was trimmed, and his facial structure was prominently displayed.

Dominic Purcell and Wentworth Miller on the set of "Prison Break," 2005 | Source: Getty Images

Dominic Purcell and Wentworth Miller on the set of “Prison Break,” 2005 | Source: Getty Images

At the Hangar 8 event in August 2005 in Santa Monica, Miller’s appearance showed slight changes. His hair remained short, but there was a slightly more textured look.

Wentworth Miller attends "Prison Break" launch party on August 22, 2005, in Santa Monica, California. | Source: Getty Images

Wentworth Miller attends “Prison Break” launch party on August 22, 2005, in Santa Monica, California. | Source: Getty Images

At the Fox Fall Casino Party in October of that year, Miller’s skin appeared slightly more tanned. He chose a dark jacket over a light-colored shirt, which created a slightly more polished casual look. His physique continued to appear lean and fit.

Wentworth Miller during FOX Fall Casino party on October 24, 2005, in Hollywood, California. | Source: Getty Images

Wentworth Miller during FOX Fall Casino party on October 24, 2005, in Hollywood, California. | Source: Getty Images

The next month, the star appeared on “The Tonight Show with Jay Leno,” and kept his look simple and consistent. His hair was short and neatly groomed, and he remained clean-shaven. He wore a black suit paired with a light blue shirt unbuttoned at the collar.

Wentworth Miller during an interview with host Jay Leno on November 21, 2005 | Source: Getty Images

Wentworth Miller during an interview with host Jay Leno on November 21, 2005 | Source: Getty Images

On January 10, 2006, Miller attended the 32nd Annual People’s Choice Awards, where he accepted the award for Favorite New TV Drama for “Prison Break.” He maintained a polished and formal appearance, and his physique appeared consistent with his appearances in 2005.

Wentworth Miller at the 32nd Annual People's Choice Awards on January 10, 2006 | Source: Getty Images

Wentworth Miller at the 32nd Annual People’s Choice Awards on January 10, 2006 | Source: Getty Images

During the Fox 2006 Golden Globes after party with Sarah Wayne Callies, Miller’s appearance was similar to the previous week. He wore a black suit, which added a touch of casual elegance to his look, and his body shape remained consistent, still lean and athletic.

Sarah Wayne Callies and Wentworth Miller attend the Fox 2006 Golden Globes after party on January 16, 2006 | Source: Getty Images

Sarah Wayne Callies and Wentworth Miller attend the Fox 2006 Golden Globes after party on January 16, 2006 | Source: Getty Images

At the Fox Winter TCA party, Miller’s appearance was sharp and stylish. His hair was short, neatly cut, and slightly spiked at the front. He wore a brown coat over a darker sweater, giving him a sophisticated yet relaxed look.

Wentworth Miller attends the Fox Winter TCA party on January 17, 2006, in Hollywood, California. | Source: Getty Images

Wentworth Miller attends the Fox Winter TCA party on January 17, 2006, in Hollywood, California. | Source: Getty Images

During this outing in May 2006 in Los Angeles, Miller’s look was more casual. His overall appearance was laid-back and comfortable, suitable for a casual day out.

Wentworth Miller seen on May 21, 2006, in Los Angeles, California. | Source: Getty Images

Wentworth Miller seen on May 21, 2006, in Los Angeles, California. | Source: Getty Images

A few days later, Miller was seen talking over the phone in Los Angeles, as he appeared in a casual and laid-back appearance. He wore a blue t-shirt paired with beige pants, keeping his look simple and comfortable. His physique appeared lean, with no significant changes from earlier in the month.

Wentworth Miller pictured on May 23, 2006, in Los Angeles, California. | Source: Getty Images

Wentworth Miller pictured on May 23, 2006, in Los Angeles, California. | Source: Getty Images

The following month, the actor attended the 2006 Teen Choice Awards at the Gibson Amphitheatre, where he opted for a more polished casual look. He wore a black button-down shirt, left untucked, blending a casual and slightly formal style.

Wentworth attends the 2006 Teen Choice Awards on August 20, 2006, in Universal City, California. | Source: Getty Images

Wentworth attends the 2006 Teen Choice Awards on August 20, 2006, in Universal City, California. | Source: Getty Images

At the 58th Annual Primetime Emmy Awards, Miller showcased a formal and elegant look. He wore a classic black tuxedo with a crisp white dress shirt and a black bow tie, presenting a polished and sophisticated appearance.

Wentworth Miller during 58th Annual Primetime Emmy Awards on August 27, 2006, in Los Angeles, California. | Source: Getty Images

Wentworth Miller during 58th Annual Primetime Emmy Awards on August 27, 2006, in Los Angeles, California. | Source: Getty Images

During his interview at the Four Seasons Hotel the next day, Miller’s appearance was slightly more relaxed but still sharp. He wore a checkered, open-collared shirt with a baseball cap, giving him an approachable look.

Wentworth Miller talks at the Four Season's Hotel on August 28, 2006, in Los Angeles, California. | Source: Getty Images

Wentworth Miller talks at the Four Season’s Hotel on August 28, 2006, in Los Angeles, California. | Source: Getty Images

On October 9, 2006, at the Majestic Hotel in Cannes, France, Miller maintained a clean and polished appearance. His hair was short and neatly styled, with a slight wave for added texture.

Wentworth Miller photographed at the Majestic Hotel on October 9, 2006, in Cannes, France. | Source: Getty Images

Wentworth Miller photographed at the Majestic Hotel on October 9, 2006, in Cannes, France. | Source: Getty Images

During this appearance at the FOX Fall 2006 Eco-Casino Party, Miller’s look was slightly more casual but still stylish. He wore a dark, fitted jacket over a gray t-shirt, which gave him a more rugged and contemporary look.

Wentworth Miller attends the FOX Fall 2006 Eco-Casino party on October 23, 2006 | Source: Getty Images

Wentworth Miller attends the FOX Fall 2006 Eco-Casino party on October 23, 2006 | Source: Getty Images

Miller in 2007

In March 2007, Miller attended a press conference and a fan meeting in Seoul, South Korea. He was pictured holding two stuffed animals and a drawing of himself.

Wentworth Miller appears at a press conference and a fan meeting on March 23, 2007, in Seoul, South Korea. | Source: Getty Images

Wentworth Miller appears at a press conference and a fan meeting on March 23, 2007, in Seoul, South Korea. | Source: Getty Images

In July of that year, the television star attended the Fox TCA Party in Los Angeles and opted for a white open-collared shirt with dark trousers for the event.

Wentworth Miller at the FOX TCA party on July 23, 2007, in Santa Monica, California. | Source: Getty Images

Wentworth Miller at the FOX TCA party on July 23, 2007, in Santa Monica, California. | Source: Getty Images

During the “Prison Break” press conference in Beverly Hills, California, in September of that year, Miller’s appearance remained consistent. He was pictured wearing a light blue checkered shirt paired with jeans.

Wentworth Miller at the "Prison Break" press conference on September 14, 2007, in Beverly Hills, California. | Source: Getty Images

Wentworth Miller at the “Prison Break” press conference on September 14, 2007, in Beverly Hills, California. | Source: Getty Images

In March 2007, during a press event in Shanghai, China, Miller had a clean-shaven face, maintaining his defined jawline. The actor wore a navy blue dress shirt as he smiled at the camera.

Wentworth Miller during an interview on March 17, 2009, in Shanghai, China. | Source: Getty Images

Wentworth Miller during an interview on March 17, 2009, in Shanghai, China. | Source: Getty Images

The next month, he attended a commercial event and arrived for the occasion wearing glasses, a gray jacket over a white unbuttoned shirt paired with black pants.

Wentworth Miller arrives for a commercial event on April 18, 2009, in Shanghai, China. | Source: Getty Images

Wentworth Miller arrives for a commercial event on April 18, 2009, in Shanghai, China. | Source: Getty Images

Three months later, Miller appeared on the set of “Law & Order: Special Victims Unit” in New York. His look was more casual and practical, fitting for his role, and he seemed to have a slightly fuller face.

Wentworth Miller on the set of "Law & Order: Special Victims Unit," 2009 | Source: Getty Images

Wentworth Miller on the set of “Law & Order: Special Victims Unit,” 2009 | Source: Getty Images